Cov ntshav biomarker puas tuaj yeem pab kwv yees Alzheimer's kev pheej hmoo?

Ib txoj kev tshawb fawb tshiab qhia tias astrocytes, ib hom hlwb hlwb, yog qhov tseem ceeb rau kev sib txuas amyloid-β nrog rau cov theem pib ntawm tau pathology.Karyna Bartashevich / Stocksy

• Reactive astrocytes, ib hom hlwb hlwb, tuaj yeem pab cov kws tshawb fawb nkag siab tias vim li cas qee cov neeg uas muaj kev paub txog kev noj qab haus huv thiab amyloid-β deposits hauv lawv lub hlwb tsis tsim lwm yam cim ntawm Alzheimer's, xws li tangled tau proteins.
• Ib txoj kev tshawb fawb nrog ntau dua 1,000 tus neeg koom tau saib ntawm biomarkers thiab pom tias amyloid-β tsuas yog txuas rau qib tau nce hauv cov tib neeg uas muaj cov cim qhia ntawm astrocyte reactivity.
• Cov kev tshawb pom qhia tias astrocytes tseem ceeb rau kev sib txuas ntawm amyloid-β nrog rau cov theem pib ntawm tau pathology, uas tuaj yeem hloov pauv peb txhais li cas thaum ntxov Alzheimer's disease.

Kev sib sau ntawm amyloid plaques thiab tangled tau proteins nyob rau hauv lub hlwb tau ntev tau suav hais tias yog thawj qhov ua rau.Alzheimer's Disease (AD).

Kev txhim kho yeeb tshuaj tau tsom mus rau kev tsom mus rau lub hom phiaj ntawm amyloid thiab tau, tsis quav ntsej lub luag haujlwm ntawm lwm lub hlwb, xws li cov kab mob neuroimmune.

Tam sim no, kev tshawb fawb tshiab los ntawm University of Pittsburgh Tsev Kawm Ntawv Tshuaj Kho Mob qhia tias astrocytes, uas yog lub hnub qub-zoo li lub hlwb hlwb, ua lub luag haujlwm tseem ceeb hauv kev txiav txim siab txog kev nce qib ntawm Alzheimer's.

AstrocytesTrusted Sourcemuaj ntau nyob rau hauv lub paj hlwb.Nrog rau lwm cov hlwb glial, lub hlwb cov neeg nyob hauv lub cev tiv thaiv kab mob, astrocytes txhawb cov neurons los ntawm kev muab lawv nrog cov as-ham, oxygen, thiab tiv thaiv cov kab mob.

Yav dhau los lub luag haujlwm ntawm astrocytes hauv kev sib txuas lus neuronal tau raug saib xyuas txij li glial hlwb tsis ua hluav taws xob zoo li neurons.Tab sis University of Pittsburg txoj kev kawm nyuaj rau qhov kev xav no thiab ua rau pom lub luag haujlwm tseem ceeb ntawm astrocytes hauv hlwb kev noj qab haus huv thiab kab mob.

Cov kev tshawb pom tau tshaj tawm tsis ntev los no hauvNature MedicineTrusted Source.

Cov kev tshawb fawb yav dhau los qhia tau hais tias kev cuam tshuam hauv lub hlwb cov txheej txheem dhau ntawm amyloid lub nra, xws li nce lub hlwb mob, tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev pib ua cov kab mob pathological ntawm neuronal kev tuag uas ua rau kev nkag siab sai hauv Alzheimer's.

Hauv txoj kev tshawb fawb tshiab no, cov kws tshawb nrhiav tau kuaj ntshav rau 1,000 tus neeg koom los ntawm peb qhov kev tshawb fawb sib cais uas muaj kev paub txog kev noj qab haus huv cov neeg laus nrog thiab tsis muaj amyloid buildup.

Lawv tau soj ntsuam cov ntshav kuaj los ntsuam xyuas biomarkers ntawm astrocyte reactivity, tshwj xeeb tshaj yog glial fibrillary acidic protein (GFAP), ua ke nrog cov muaj pathological tau.

Cov kws tshawb fawb tau tshawb pom tias tsuas yog cov neeg uas muaj ob qho tib si amyloid lub nra thiab cov ntshav cov cim qhia qhov txawv txav astrocyte ua kom lossis ua kom muaj zog tuaj yeem tsim cov tsos mob Alzheimer's yav tom ntej.